Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

查看全文 作　　者：Roberto Herrera-[1]Goepfert;Jesús K Yamamoto-[2]Furusho;Luis F Oate-Oca[3]a;Margarita Camorlinga-[4]Ponce;Leopoldo Mu[4]oz;Jorge A Ruiz-[5]Morales;Gilberto Vargas-[6]Alarcón;Julio [5]Granados;Cellular Biology [6]Section

机构地区：[1]Department of Pathology, Institute Nacional de Cancerologia (INCan), Mexico City, Mexico;[2]Department of Immunology and Rheumatology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico Department of Gastroenterology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico;[3]Department of Gastroenterology (INCan), Mexico City, Mexico;[4]Medical Research Unit on Infectious and Parasitic Diseases, Hospital de Pediatria, Centro Medico Nacional Siglo XXI (CMN-SXXI), Institute Mexicano del Seguro Social (IMSS), Mexico City, Mexico;[5]Department of Immunology and Rheumatology, Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico;[6]Department of Physiology, Institute Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第48期,共6页

基　　金：Supported in part by Consejo Nacional de Ciencia y Tecnologiagrant, Mexico, No. 153237 摘　　要：AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. 关键词：慢性胃炎胃癌墨西哥基因表达

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Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

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