Pd(OAc)2 catalyzed synthesis of heteroaryl-substituted 1,8-naphthyridine derivatives via C-N-coupling reactions of chloronaphthyridines

查看全文 作　　者：Shou Wen Jin Bin Liu Wan Zhi [1]Chen 机构地区：[1]Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, China 出　　处：《Chinese Chemical Letters》索引2007年第18卷第4期,共4页 基　　金：the National Natural Science Foundation of China (no. 20572096) ; the Zhejiang Provincial Science Foundation (Grant R405066). 摘　　要：An efficient route to synthesize the heteroaryl-substituted 1,8-naphthyridine derivatives was described.Eight 2-heteroaryl-and 2,7-diheteroaryl-1,8-naphthyridine derivatives were obtained through palladium-catalyzed C-N-coupling reactions of chloro-naphthyridines with imidazole,benzimidazole,morpholine,3,5-dimethylpyrazole,and phthalimide in moderate to good yields. 关 键 词：异芳基取代1,8-萘啶衍生物 钯催化剂 催化合成 C-N偶联反应 氯萘啶