Microwave-prompted rapid and efficient synthesis of 3-alkyl substituted imidazo[1,5-a]pyridines

查看全文 作　　者：Lai Bao [1]Wang;Jia [1]Pan;Can Ling [1]Tang;Xiu Ren [2]Bu;Jie [1]Wang 机构地区：[1]College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China;[2]Department of Chemistry, Clark Atlanta University, Atlanta, GA 30314, USA 出　　处：《Chinese Chemical Letters》索引2007年第18卷第4期,共3页 基　　金：the Jiangsu Provincial Natural Science Foundation of China (No. BK2004092); the Scientific Research Foundation for the Returned 0verseas Chinese Scholars from State Education Ministry of China; Nanjing University Talent Development Foundation. 摘　　要：Under regular heating and microwave irradiation,3-alkyl substituted imidazo[1,5-a]pyridines were synthesized from 2,2'-pyridil,di-2-pyridyl ketone and aliphatic aldehydes in the presence of ammonium acetate and acetic acid.Compared to thetraditional heating condition,the reaction time under microwave irradiation was shorter and 3-alkyl imidazo[1,5-a]pyridines weregiven in higher yield. 关 键 词：3-烷基取代咪唑[1,5-a]吡啶 微波辐射 敏捷合成 优化条件