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Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity

查看全文 作　　者：Leo K [1]Cheng;Rie [1]Komuro;Travis M [1]Austin;Martin L [2]Buist;Andrew J [3]Pullan 高影响力作者 机构地区：[1]Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand;[2]Division of Bioengineering, National University of Singapore,Singapore;[3]Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand,Department of Engineering Science, The University of Auckland高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第9期,共6页高影响力期刊 基　　金：Supported in part by NIH grant R01 DK64775 摘　　要：One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach. 关 键 词：胃肠电活动 正常活动 异常活动 实际解剖多尺度模型
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