Clinical heterogeneity in autoimmune acute liver failure

查看全文 作　　者：Norberto C Chavez-[1]Tapia;Julio Martinez-[1]Salgado;Julio [2]Granados;Misael [1]Uribe;Felix I Tellez-[1]Avila

机构地区：[1]Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoJulio Granados, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;[2]Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第12期,共4页

摘　　要：AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids. 关键词：自体免疫性肝炎急性肝衰竭临床异质性皮质类固醇

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Clinical heterogeneity in autoimmune acute liver failure

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