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Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

查看全文 作　　者：MS El-[1]Raziky;M El-[1]Hawary;G [2]Esmat;AM [3]Abouzied;N El-[1]Koofy;N [1]Mohsen;S [1]Mansour;A [3]Shaheen;M Abdel [3]Hamid;H El-[1]Karaksy 高影响力作者 机构地区：[1]Departments of Pediatrics Cairo University, Cairo, Egypt;[2]Departments of Tropical Medicine Cairo University,Cairo, Egypt;[3]Tropical Medicine Research Institute, Cairo, Egypt高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第12期,共5页高影响力期刊 基　　金：Supported by the Sustainable Sciences Institute, United States as part of the small grants program 摘　　要：AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. 关 键 词：埃及 儿童 无症状性感染 丙型肝炎病毒感染 流行性 危险因素
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