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Biomarkers for radiation-induced small bowel epithelial damage:An emerging role for plasma Citrulline

查看全文 作  者:Ludy [1]Lutgens;Philippe [1]Lambin 高影响力作者 机构地区:[1]Department of Radiation Oncology (Maastro), GROW Research Institute, University of Maastricht, Maastricht 6200 MD, The Netherlands高影响力机构 出  处:《World Journal of Gastroenterology》索引2007年第13卷第22期,共10页高影响力期刊 摘  要:Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specif ic objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail. 关 键 词:小肠上皮损害 等离子体 瓜氨酸 放射损害 生物标记
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