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Long-term prognosis in patients with severe late radiation enteropathy:A prospective cohort study

查看全文 作　　者：Annette [1]Larsen;Jon B [2]Reitan;Steinar T [3]Aase;Martin Hauer-[4]Jensen 高影响力作者 机构地区：[1]Institute of Internal Medicine,Department of Oncology,Haukeland University Hospital N-5021 Bergen,Norway;[2]Department of Oncology,The Norwegian Radium Hospital N-0310 Oslo,Norway;[3]Department of Pathology,Haukeland University Hospital N-5021 Bergen,Norway;[4]Departments of Surgery and Pathology,University of Arkansas for Medical Sciences,Central Arkansas Veterans Healthcare System,Little Rock,Arkansas,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2007年第13卷第26期,共4页高影响力期刊 摘　　要：AIM: To assess persistent symptoms and mortality in a cohort of patients with severe (grade 3-4) radiation enteropathy,59 patients were followed up after 15-18 years. METHODS: Fifty-nine patients were prospectively enrolled by twelve surgical departments. Primary malignant disease,radiation therapy and surgical management were recorded at inclusion. The cause of death or persistence of symptoms was examined in public death records or by interview of survivors. RESULTS: Thirty-nine patients had received radiation therapy for gynaecological cancers,twelve for urological cancers,four for gastrointestinal cancers and four for other malignancies. Forty-five patients (76%) required surgical intervention. Complications occurred in 11 (25%) operated patients. Forty-seven patients had died at the time of follow-up,seven (12%) died as a direct result of radiation enteropathy,while radiation enteropathy contributed to death in an additional seven patients. Four of the twelve surviving patients suffered from chronic debilitating symptoms of radiation enteropathy,while three had moderate symptoms. CONCLUSION: Patients with severe delayed radiation enteropathy have a high risk of persistence of symptoms after surgery. At least one in ten patients dies from radiation-induced bowel injury. 关 键 词：辐射 肠疾病 疾病预防 治疗
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