New therapeutic opportunities for Hepatitis C based on small RNA

查看全文 作　　者：Qiu-wei [1]Pan;Scot D [2]Henry;Bob J [3]Scholte;Hugo W [2]Tilanus;Harry LA [4]Janssen;Luc JW van der [2]Laan

机构地区：[1]Departments of Gastroenterology & Hepatology and Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands;[2]Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands;[3]Department of Cell Biology, Erasmus MC- University Medical Centre, Rotterdam, The Netherlands;[4]Department of Gastroenterology & Hepatology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第33期,共6页

摘　　要：Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. 关键词：RNA 肝炎治疗方法寡核苷酸滤过性毒菌

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New therapeutic opportunities for Hepatitis C based on small RNA

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