IL-10-Producing Type 1 Regulatory T Cells and Allergy

查看全文 作　　者：Kui [1]Wu;Yutian [1]Bi;Kun [2]Sun;Changzheng [2]Wang

机构地区：[1]Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China;[2]Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

出　　处：《Cellular & Molecular Immunology》索引2007年第4卷第4期,共7页

摘　　要：As an important subset of regulatory T(Treg) cells,IL-10-producing type 1 regulatory T cells(Tr1) ,have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells) . Similar to nTreg cells,Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Tr1 phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and β2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation,such as eosinophils,mast cells,basophils,through producing IL-10,and perhaps TGF-β. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases. 关键词：变态反应过敏症 T细胞免疫机制

相关文献

参考文献（10）
引证文献（10）
耦合文献（0）

参考文献(10)

引证文献(10)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

IL-10-Producing Type 1 Regulatory T Cells and Allergy

参考文献(10)

引证文献(10)

用户提示