Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up

查看全文 作　　者：Renato [1]Caviglia;Mentore [1]Ribolsi;Marina [1]Rizzi;Sara [1]Emerenziani;Maria Laura [1]Annunziata;Michele [1]Cicala

机构地区：[1]Department of Digestive Diseases, Campus Bio-Medico University, Rome, Italy

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第39期,共7页

摘　　要：AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. 关键词：肠炎克罗恩氏病溃疡性结肠炎治疗方法

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Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up

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