An optimized ^(13)C-urea breath test for the diagnosis of H pylori infection

查看全文 作　　者：Germán Campuzano-[1,2]Maya

机构地区：[1]Professor,Ad honorem,School of Medicine,University of Antioquia,Medellín,Colombia;[2]Medical Director,Laboratorio Clínico Hematológico~,Medellín,Colombia

出　　处：《World Journal of Gastroenterology》索引2007年第13卷第41期,共11页

摘　　要：AIM: To validate an optimized 13C-urea breath test (13C-UBT) protocol for the diagnosis of H pylori infection that is cost-efficient and maintains excellent diagnostic accuracy. METHODS: 70 healthy volunteers were tested with two simplified 13C-UBT protocols,with test meal (Protocol 2) and without test meal (Protocol 1). Breath samples were collected at 10,20 and 30 min after ingestion of 50 mg 13C-urea dissolved in 10 mL of water,taken as a single swallow,followed by 200 mL of water (pH 6.0) and a circular motion around the waistline to homogenize the urea solution. Performance of both protocols was analyzed at various cut-off values. Results were validated against the European protocol. RESULTS: According to the reference protocol,65.7% individuals were positive for H pylori infection and 34.3% were negative. There were no significant differences in the ability of both protocols to correctly identify positive and negative H pylori individuals. However,only Protocol 1 with no test meal achieved accuracy,sensitivity,specificity,positive and negative predictive values of 100%. The highest values achieved by Protocol 2 were 98.57%,97.83%,100%,100% and 100%,respectively. CONCLUSION: A 10 min,50 mg 13C-UBT with no test meal using a cut-off value of 2-2.5 is a highly accurate test for the diagnosis of H pylori infection at a reduced cost. 关键词：幽门螺杆菌诊断方法成本准确度

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An optimized ^(13)C-urea breath test for the diagnosis of H pylori infection

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