Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

查看全文 作　　者：Lihua [1,2]Shi;Jacek [3]Bielawski;Jinye [1,2]Mu;Haili [1,2]Dong;Chong [1,2]Teng;Jian [1]Zhang;Xiaohui [1]Yang;Nario [4]Tomishige;Kentaro [4]Hanada;Yusuf A [3]Hannun;Jianru [1]Zuo

机构地区：[1]National Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences,Datun Road, Beijing 100101, China;[2]Graduate School, Chinese Academy of Sciences, 1914 Yuquan Road, Beijing 100049, China;[3]Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC29425, USA;[4]Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku,Tokyo 162-8640, Japan

出　　处：《Cell Research》索引2007年第17卷第12期,共11页

基　　金：Acknowledgments We would like to thank the Arabidopsis Biological Resources Center (Ohio State University, USA) for providing seeds and Dr Teresa Dunn (Uniformed Services University of the Health Sciences, USA) for providing yeast strains. We are grateful to Drs Weicai Yang, Yongbiao Xue (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences) and De Ye (China Agriculture University) for critical reading of the manuscript. This work was supported by grants from the National Natural Science Foundation of China (30330360, 30125025 and 30221002) and the Chinese Academy of Sciences to Jianru Zuo. 摘　　要：Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 关键词：PCD ROIs 鞘脂氧介质细胞死亡

相关文献

参考文献（58）
引证文献（15）
耦合文献（9）

参考文献(58)

引证文献(15)

耦合文献(9)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis

参考文献(58)

引证文献(15)

耦合文献(9)

用户提示