MODIFIED CLASSIC RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHINESE HAN POPULATION

查看全文 作　　者：Han-bin [1]Cui;Sheng-huang [2]Wang;Dong-qi [3]Wang;Chang-cong [3]Cui;Xin-yi [1]Chen;Xiao-min [2]Chen;Zheng [4]Zhang;Hong-kao [5]Zhang;Feng [4]Bai;Joseph B [6]Muhlestein

机构地区：[1]Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an 710068;[2]Department of Cardiology, Zhejiang Provincial Ningbo City Hospital, Ningbo 315012;[3]Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061;[4]Department of Cardiology, First Hospital of Lanzhou Medical College, Lanzhou 730000;[5]Deoartment of Cardiology, Hubei Provincial Shiyan City Hospital, Shiyan 442000;[6]Cardiology Center of LDS Hospital, Salt Lake City 84132, USA

出　　处：《Chinese Medical Sciences Journal》索引2007年第22卷第4期,共8页

基　　金：Supported by a grant from Desert Foundation (2003),Salt Lake City,USA 摘　　要：Objective To investigate the levels of cardiovascular disease risk factors and their relations to clinical phenotype associated with coronary artery disease(CAD).Methods The subjects were recruited from five independent cardiovascular centers.Coronary angiography was employed to define the CAD with stenosis in each major vessel ≥70% and control with stenosis <10% in every lesion.The classic risk factors including family history,body mass index,smoking habits,hypertension,diabetes mellitus,and serum lipid levels were surveyed according to established criteria.Associations between risk levels and clinical phenotypes were assessed by case control and correlation analysis.Results A total of 762 individuals were collected,including 481 men and 281 women,aged from 17 to 81(mean 60±10) years.The patients with CAD accounted for 55.5% of all participants,and controls 44.5%,respectively.Compared with the pattern in published data,our study showed that mean serum high density lipoprotein cholesterol(HDL-C) level was significantly lower(P<0.001) and triglycerides was significantly higher(P<0.001),while total cholesterol(TC) and low density lipoprotein cholesterol levels were comparative(both P>0.05).The prevalence of low HDL-C(<40 g/L) and hypertriglyceridemia(>150 g/L) were 27.2% and 41.4%,respectively.Mean serum levels of HDL-C and apolipoprotein A1 were significantly higher in female subjects than in male(P<0.001).Lower HDL-C functioned as an independent risk factor for CAD only in men(RR=2.8,95%CI:1.5-4.2,P<0.001),yet increased non-HDL cholesterol combined with diabetes mellitus and obesity seemed to play a key role in the development ofCAD in women.Similarity in risk association with CAD was found for hypertension and TC/HDL ratio in male and female subjects,while family history had no relationship with the presence of CAD.Conclusion It is remarkable that emphasis of intervention in future should be given on the prevalent low serum HDL-C and its strong risk correlation with the presence of CAD in male subjects of Chinese Han population. 关键词：中国人汉族冠心病高密度脂蛋白胆固醇风险因子

相关文献

参考文献（27）
引证文献（2）
耦合文献（701）

参考文献(27)

引证文献(2)

耦合文献(701)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

MODIFIED CLASSIC RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHINESE HAN POPULATION

参考文献(27)

引证文献(2)

耦合文献(701)

用户提示