Role of the intestinal barrier in inflammatory bowel disease

查看全文 作　　者：Mike G [1]Laukoetter;Porfirio [2]Nava;Asma [2]Nusrat

机构地区：[1]Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, United States Department of General Surgery, University of Muenster, Muenster 48149, Germany;[2]Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, United States

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第3期,共7页

基　　金：Grants from the German Research Foundation (Deutsche Forschungsgemeinschaft La 2359/1-1 to M.L.);National Institutes of Health (DK 55679, DK 59888 to A.N.);Crohn’s and Colitis Foundation of America (to A.N.) 摘　　要：A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic interface between the host and its environment. Cell polarity and structural properties of the epithelium is complex and is important in the development of epithelial barrier function. Epithelial cells associate with each other via a series of intercellular junctions. The apical most intercellular junctional complex referred to as the Apical Junction Complex (AJC) is important in not only cell-cell recognition, but also in the regulation of paracellular movement of fluid and solutes. Defects in the intestinal epithelial barrier function have been observed in a number of intestinal disorders such as inflammatory bowel disease (IBD). It is now becoming evident that an aberrant epithelial barrier function plays a central role in the pathophysiology of IBD. Thus, a better understanding of the intestinal epithelial barrier structure and function in healthy and disease states such as IBD will foster new ideas for the development of therapies for such chronic disorders. 关键词：炎性肠病障碍功能紧密接头症状

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Role of the intestinal barrier in inflammatory bowel disease

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