H pylori eradication:A randomized prospective study of triple therapy with or without ecabet sodium

查看全文 作　　者：Hyung Wook [1]Kim;Gwang Ha [2]Kim;Jong Yun [2]Cheong;Ung Suk [1]Yang;Seung Keun [3]Park;Chul Soo [2]Song;Dae Hwan [2]Kang;Geun Am [2]Song

机构地区：[1]Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Korea;[2]Department of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Korea;[3]Department of Internal Medicine, Maryknoll Hospital, Busan, Korea

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第6期,共5页

基　　金：An unrestricted grant by JEIL Pharm.Co.,Ltd.,Korea 摘　　要：AIM: To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate. METHODS: Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative 13C-urea breath test 6-8 wk after completion of treatment. RESULTS: After completion of therapy, 194/257 patients showed negative 13C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups. CONCLUSION: Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori. 关键词：幽门螺杆菌细菌感染消化系统疾病治疗

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H pylori eradication:A randomized prospective study of triple therapy with or without ecabet sodium

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