Increased hepcidin expression in colorectal carcinogenesis

查看全文 作　　者：Douglas G [1]Ward;Keith [1]Roberts;Matthew J [1]Brookes;Howard [1]Joy;Ashley [1]Martin;Tariq [1]Ismail;Robert [1]Spychal;Tariq [1]Iqbal;Chris [1]Tselepis

机构地区：[1]CRUK Institute for Cancer Studies,University of Birmingham, Birmingham B15 2TH,United Kingdom

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第9期,共7页

摘　　要：AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. 关键词：结肠癌贫血症铁离子质谱分析

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Increased hepcidin expression in colorectal carcinogenesis

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