维普中文期刊产品整合服务

Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

查看全文 作　　者：Kenichi [1]Hakamada;Norihisa [1]Kimura;Takuya [1]Miura;Hajime [1]Morohashi;Keinosuke [1]Ishido;Masaki [1]Nara;Yoshikazu [1]Toyoki;Shunji [1]Narumi;Mutsuo [1]Sasaki 高影响力作者 机构地区：[1]Department of Gastroenterological Surgery,Hirosaki University Graduate School of Medicine,Japan高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第9期,共8页高影响力期刊 摘　　要：AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body. 关 键 词：肝细胞癌 肝切除术 血管入侵 预兆因子 凝血素
相关文献

参考文献(40)

引证文献(5)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费