Tumor suppressor and hepatocellular carcinoma

查看全文 作　　者：Juliette [1]Martin;Jean-Franois [1]Dufour

机构地区：[1]Department of ClinicalPharmacology,Bern,CH-3010,Switzerland

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第11期,共14页

基　　金：The Stiftung für die Leberkranheiten,the EASLfellowship to JM and the Swiss National Foundation grant#3100-063696 to JFD 摘　　要：A few signaling pathways are driving the growth of hepatocellular carcinoma.Each of these pathways possesses negative regulators.These enzymes,which normally suppress unchecked cell proliferation,are circumvented in the oncogenic process,either the overactivity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective.The loss of several key tumor suppressors has been described in hepatocellular carcinoma.Here,we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma. 关键词：肝细胞癌肿瘤抑制剂治疗方法肝致癌作用

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Tumor suppressor and hepatocellular carcinoma

参考文献(196)

引证文献(14)

耦合文献(344)

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