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Effect of infliximab on small bowel stenoses in patients with Crohn's disease

查看全文 作　　者：Nadia [1,2]Pallotta;Fausto [1,2]Barberani;Naima Abdulkadir [1,2]Hassan;Danila [1,2]Guagnozzi;Giuseppina [1,2]Vincoli;Enrico [1,2]Corazziari 高影响力作者 机构地区：[1]Department of Clinical Science, University of Rome Sapienza;[2]Rome COU Gastroenterology S. Camillo De Lellis Hospital Rieti, Rome 00168, Italy高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第12期,共6页高影响力期刊 摘　　要：AIM: To assess prospectively small bowel stenoses in Crohn's disease (CD) patients treated with infliximab using Small Intestine Contrast Ultrasonography (SICUS). METHODS: Twenty patients (M 12, age, 42.7 ± 11.8 years), 15 of whom showed obstructive symptoms indicating the presence of small bowel stenosis, and 5 without stenosis, were treated with infliximab (5 mg/kg at wk 0, 2, 6 and 5 mg/kg every 8 wk thereafter) for steroid refractoriness, fistulizing disease, or to avoid high-risk surgery. SICUS was performed at the induction phase and at regular time intervals during the follow-up period of 34.7 ± 16.1 mo (range 7-58). Small bowel stenoses were detected by SICUS, endoscopy and MRI. RESULTS: In no case was progression of stenoses or the appearance of new ones seen. Of the 15 patients with stenosis, 5 stopped treatment after the induction phase (2 for no response, 3 for drug intolerance, one of whom showed complete regression of one stenosis). Among the remaining 10 patients, a complete regression of 8 stenoses (1 stenosis in 5 patients and 3 stenoses in one patient) was observed after 6-22 infliximab infusions. CONCLUSION: In patients with CD treated with infliximab we observed: (a) No progression of small bowel stenosis and no appearance of new ones, (b) Complete regression of 1/22 stenosis after the induction phase and of 8/15 (53.3%) stenosis after 6-22 infusionsduring maintenance therapy. 关 键 词：Crohn疾病 节段性回肠炎 超声检查 症状
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