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Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study

查看全文 作　　者：Zhe [1]Shen;You-Ming [1]Li;Chao-Hui [1]Yu;Yi [2]Shen;Lei [1]Xu;Cheng-Fu [1]Xu;Jin-Jin [1]Chen;Hua [1]Ye;Gen-Yun [3]Xu 高影响力作者 机构地区：[1]Department of Gastroenterology, The First Affiliated Hospital, Medicine School, Zhejiang University, Hangzhou 310003, Zhejiang Province, China;[2]Department of Statistics, Medicine School, Zhejiang University, Hangzhou 310000, Zhejiang Province, China;[3]Department of Clinical Laboratory, The First Affiliated Hospital, Medicine School, Zhejiang University, Hangzhou 310003, Zhejiang Province, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第14期,共7页高影响力期刊 摘　　要：AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.METHODS:Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS:Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.CONCLUSION:The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned. 关 键 词：酒精 肝损伤 流行病学 治疗方法
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