The effects of ischemia-reperfusion injury and hepatic artery ischemia on CD14 expression in canine auto-transplantation livers

查看全文 作　　者：Jinkai Xu Yiming Li Peijun [1]Ye

机构地区：[1]Department of General Surgery, the Second Affiliated Hospital of Xi' an Jiaotong University, Xi' an 710004, Shanxi Province, China

出　　处：《Journal of Nanjing Medical University》索引2008年第22卷第3期,共4页

基　　金：This work was supported by National Nature Science Fund(30571765) 摘　　要：Objective: To study the effect of ischemia-reperfusion injury(IRI) and hepatic artery ischemia(HAI) on CD14 expression in canine auto-transplantation livers. Methods:Liver orthotopic auto-transplantation models were applied with 30 healthy male Xi’an canines which were randomly divided into a control group, simultaneous reperfusion(SR) group and HAI group. CD14 protein expression, Malonaldehyde (MDA) Contents in hepatic tissues and ALT values in serum were detected, and the pathological changes of hepatic tissues was investigated under the light microscopy. Results:The level of CD14 protein expression in SR and HAI group tended to be time-dependent and both higher than controls with statistical significance(P < 0.01); The peak values of these two groups both occurred at 4 h, but the level in HAI group (11.94± 0.43) was evidently higher than that in SR group(3.04± 0.34). MDA contents in liver tissue, ALT values in serum and pathological changes showed the same changing tendency as CD14 expression. Conclusion:① Up-regula- tion of CD14 expression may be the receptor-mechanism of Kupffer cells(KCs) activation in liver transplantation. ② HAI can up- regulate CD14 expression after portal vein reperfusion, improve the activity of KCs further more, increase OFRs production and coop- erate with portal reperfusion, and finally aggravate the grafts injury. 关键词：肝脏移植肝动脉局部缺血 KUPFFER细胞缺血-再灌注损伤

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The effects of ischemia-reperfusion injury and hepatic artery ischemia on CD14 expression in canine auto-transplantation livers

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