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Association of the p73 Gene G4C14-to-A4T14 Polymorphism with Increased Gastric Cancer Risk in a Northwestern Chinese Population

查看全文 作　　者：Weihua [1]Zhang;Xudong [1]Wang;Xiaodong [2]Xie;Fengxia [3]Guo;Rong [4]Yang;Yuhua [1]Liu;Shijian [2]Xu;Yajun [2]Yang 高影响力作者 机构地区：[1]Department of Gastroenterology, the Gansu Provincial Cancer Hospital, Lanzhou 730050, Gansu Province, China.;[2]School of Life Science, Lanzhou University, Lanzhou 730000, Gansu Province, China.;[3]College of Life Science and Technology, Gansu Agriculture University, Lanzhou 730070, Gansu Province,China;[4]Department of Pathology, the Gansu Provincial Cancer Hospital, Lanzhou 730050, Gansu Province. China.高影响力机构 出　　处：《Chinese Journal of Clinical Oncology》索引2008年第5卷第3期,共4页高影响力期刊 基　　金：a grant from Natural Science Foundation of Gansu Province,China(No.3ZS041-A25-013) 摘　　要：OBJECTIVE To evaluate the p73 gene G4C14-to-A4T14 double nucleotide polymorphism with both increased gastric cancer(GC) risk and different histological subtypes of GC in a northwestern Chinese population. METHODS Genotyping of the polymorphism of the p73 gene was conducted with PCR-CTPP. RESULTS All 385 GC patients including 305 diffuse-type and 80 intestinal-type cases and 412 healthy controls were investigated.The frequencies of p73 AT/AT,AT/GC,and GC/GC genotypes were 28.1%,47.1%,and 24.8% in the controls,and were 22.0%,45.0%,and 33.0% in GC cases respectively;the GC/GC homozygote frequency was higher in GC cases,mainly in diffuse type compared to the controls with OR=1.71(1.16~2.51) and 1.87 (95%CI,1.24~2.81) respectively.The results showed that carriers of the p73 G4A GC/GC homozygote had a 1.71-time higher risk of GC,especially of the diffuse-type GC compared to the controls. The carriers of the AT/GC heterozygote also had a slightly increased risk of GC cancer,mainly on intestinal-type GC.This is the first report that the p73 G4A double-nucleotide polymorphism is associated with an increased risk of diffuse-type gastric cancer. CONCLUTION The p73 G4A GC/GC genotype is associated with an increased risk of gastric cancer,especially of the GC diffuse-type. 关 键 词：P73基因 胃癌 基因多态性 病理研究 中国人
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