Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome

查看全文 作　　者：Jacqueline S [1]Barrett;Kim EK [1]Canale;Richard B [1]Gearry;Peter M [1]Irving;Peter R [1]Gibson

机构地区：[1]Monash University,Department of Medicine, and Department of Gastroenterology, Box Hill Hospital

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第32期,共5页

基　　金：Yakult Ltd, Melbourne Australia;in receipt of the Sir Robert Menzies Memorial Research Scholarship in Allied Health Sciences;Pharmatel Fresenius Kabi IBD Fellowship and the New Zealand Society of Gastroenterology-Ferring Pharmaceuticals Fellowship;a Fellowship from Nycomed. 摘　　要：AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. 关键词：小肠细菌繁殖功能性消化障碍急性肠炎症状

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Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome

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