Role of mucosal dendritic cells in inflammatory bowel disease

查看全文 作　　者：Jan Hendrik [1]Niess

机构地区：[1]Department of Internal Medicine I, Ulm University,Ulm 89031, Germany

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第33期,共11页

基　　金：The Deutsche Forschungsgemeinschaft, No. Ni575/4-1 摘　　要：The gastrointestinal innate and adaptive immune system continuously faces the challenge of potent stimuli from the commensal microflora and food constituents. These local immune responses require a tight control, the outcome of which is in most cases the induction of tolerance. Local T cell immunity is an important compartment of the specif ic intestinal immune system. T cell reactivity is programmed during the initial stage of its activation by professional presenting cells. Mucosal dendritic cells (DCs) are assumed to play key roles in regulating immune responses in the antigen-rich gastrointestinal environment. Mucosal DCs are a heterogeneous population that can either initiate (innate and adaptive) immune responses, or control intestinal inflammation and maintain tolerance. Defects in this regulation are supposed to lead to the two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses. 关键词：肠疾病粘膜枝状细胞发病机理肠炎

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Role of mucosal dendritic cells in inflammatory bowel disease

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