Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory

查看全文 作　　者：Avi [1]Levin;Oren [1]Shibolet

机构地区：[1]Liver and Gastroenterology Units, Division of Medicine, Hadassah-Hebrew University Medical Center,Jerusalem 91120, Israel

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第33期,共5页

摘　　要：Ulcerative colitis and Crohn's disease are chronic relapsing-remitting inflammatory processes of the intestinal tract. The etiology of these diseases is currently unknown. However, inflammation is hypothesized to result from inappropriate activation of mucosal immunity by luminal antigens in genetically susceptible individuals. Toll-like receptors (TLRs) are a family of transmembrane proteins that act as microbial pattern recognition receptors. They are crucial initiators of innate immune responses. The role of TLRs in the pathogenesis of inflammatory bowel disease (IBD) has not been fully elucidated. In this review, we aim to analyze the available data connecting individual TLRs to intestinal inflammation and IBD. 关键词：肠疾病消化系统疾病发病机理肠炎受体

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Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory

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