Mucosal cytokine network in inflammatory bowel disease

查看全文 作　　者：Akira [1]Andoh;Yuhki [1]Yagi;Makoto [1]Shioya;Atsushi [1]Nishida;Tomoyuki [1]Tsujikawa;Yoshihide [1]Fujiyama

机构地区：[1]Department of Medicine, Shiga University of Medical Science,Seta-Tukinowa, Otsu 520-2192, Japan

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第33期,共8页

摘　　要：Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic in-flammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina pro-pria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-α clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the bio-logical activities of recently-reported cytokines [Inter-leukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-α in the pathophysiology of IBD. 关键词：肠疾病消化系统疾病发病机理肠炎肠黏膜

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Mucosal cytokine network in inflammatory bowel disease

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