Effect of b value on monitoring therapeutic response by diffusion-weighted imaging

查看全文 作　　者：Zhao-Xia [1,2]Jiang;Wei-Jun [1,2]Peng;Wen-Tao [1,2]Li;Feng [1,2]Tang;Shi-Yuan [3]Liu;Xu-Dong [4]Qu;Jian-Hua [4]Wang;Hong-Feng [5]Lu

机构地区：[1]Department of Radiology, Affiliated Cancer Hospital of Fudan University, Shanghai 200032, China;[2]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;[3]Department of Radiology, Affiliated Changzheng Hospital of the Second Military Medical University, Shanghai 200032, China;[4]Department of Radiology, Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China;[5]Department of Pathology, Affiliated Cancer Hospital of Fudan University, Shanghai 200032, China

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第38期,共7页

基　　金：The National Natural Science Foundation of China, NO. 30470503;The Key Program of Shanghai Science and Technology Commission, NO. 04JC14074;The Foundation of Shanghai Educational commission, NO. 03J405037 摘　　要：AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS: Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated with TACE. Diffusion-weighted imaging (DWI) with various b values was performed using the same protocol before and 3 d after treatment with TACE. ADC values and CNR of each tumor pre-and post-treatment with different b factors were analyzed. Correlation between ADC values and extent of necrosis in histological specimens was analyzed by a Pearson's correlation test.RESULTS: The quality of diffusion-weighted images diminished as the b value increased. A substantial decrease in the mean lesion-to-liver CNR was observed on both pre-and post-treatment DW images, the largest difference in CNR pre-and post-treatment was manifested at a b value of 1000 s/mm2 (P = 0.036 ). The effect of therapy on diffusion early after treatment was shown by a significant increase in ADCs (P = 0.007), especially with large b factors (≥ 600 s/mm2). The mean percentage of necrotic cells present within the tumor was 76.3%-97.5%. A significant positive correlation was found between ADC values and the extent of necrosis with all b values except for b200, a higher relative coefficient between ADC values and percentage of necrosis was found on DWI with b1000 and b2000 (P= 0.002 and 0.006, respectively). CONCLUSION: An increasing b value of up to 600 s/mm2 would increase ADC contrast pre-and post-treatment, but decrease image quality. Taking into account both CNR and ADC measurement, diffusion-weighted imaging obtained with a b value of 1000 s/mm2 is recommended for monitoring early hepatic tumor response to TACE. 关键词：肝癌表观扩散系数治疗响应扩散-加权成像

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Effect of b value on monitoring therapeutic response by diffusion-weighted imaging

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