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Immunoglobulin Expression and Its Biological Significance in Cancer Cells

查看全文 作　　者：Duosha [1,2]Hu;Hui [1,2]Zheng;Haidan [1]Liu;Ming [1]Li;Wei [1]Ren;Wei [1]Liao;Zhi [1]Duan;Lili [1]Li;Ya [1,3]Cao 高影响力作者 机构地区：[1]Cancer Research Institute, Xiangya School of Medicine, Central SouthUniversity, Changsha, Hunan, China;[2]These two author contributed equally to this paper;[3]Laboratory of Tumor Molecular Biology,Cancer-Institute, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410078, China高影响力机构 出　　处：《Cellular & Molecular Immunology》索引2008年第5卷第5期,共6页高影响力期刊 基　　金：grants from China Medicine Board (No. 96655, No. 04-799);State Key Basic Research andDevelopment Plan (973) of the Ministry of Science and Technology of China (No. 2004CB518703);National High Technology Research and Development Program (863) of China (No. 2006AA02A404);Key Project of National Natural Science Foundation of China (No. 38930410, No. 30530710);National Natural Science Foundation of China (No. 39080015, No. 39400153, No. 39470299, No. 39600082, No. 69700170, No. 30171047, No. 30271218, No. 30471968, No. 30570700, No. 30772465);National Natural Science Funds for Distinguished Young Scholar (No. 39525022);Key Project of Hunan Province (04SK1001). 摘　　要：It is generally believed that the expression of a gene is restricted 'within the right place and at the right time'. This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig 'paradoxically' expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology. 关 键 词：免疫球蛋白 癌细胞 再结合 生物学
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