Natural heme oxygenase-1 inducers in hepatobiliary function

查看全文 作　　者：Giovanni Li [1]Volti;David [2]Sacerdoti;Claudia Di [1]Giacomo;Maria Luisa [1]Barcellona;Antonio [1]Scacco;Paolo [3]Murabito;Antonio [4]Biondi;Francesco [4]Basile;Diego [5,6]Gazzolo;Raul [7]Abella;Alessandro [7]Frigiola;Fabio [1]Galvano

机构地区：[1]Department of Biological Chemistry,Medical Chemistry and Molecular Biology,University of Catania;[2]Department of Clinical and Experimental Medicine,University of Padova;[3]Department of Surgery,section of Anesthesiology,University of Catania;[4]Department of Surgery,Section of General and Oncological Surgery,University of Catania;[5]Neonatal Intensive Care Unit 'Cesare Arrigo' Children Hospital;[6]Department of Pediatrics,G.Gaslini Children's University Hospital;[7]Perinatal Research Laboratory IRCSS San Donato Milanese

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第40期,共11页

基　　金：Grants (ex 60%) from MURST (Ministero dell’ Università e della Ricerca Scientifica e Tecnologica),Rome,Italy 摘　　要：Many physiological effects of natural antioxidants,their extracts or their major active components,have been reported in recent decades.Most of these compounds are characterized by a phenolic structure,similar to that of α-tocopherol,and present antioxidant proper-ties that have been demonstrated both in vitro and in vivo.Polyphenols may increase the capacity of en-dogenous antioxidant defences and modulate the cellu-lar redox state.Changes in the cellular redox state may have wide-ranging consequences for cellular growth and differentiation.The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reac-tivity toward free radicals and their capacity to prevent the oxidation of important intracellular components.However,in recent years a possible novel aspect in the mode of action of these compounds has been sug-gested; that is,the ultimate stimulation of the heme oxygenase-1 (HO-1) pathway is likely to account for the established and powerful antioxidant/anti-inflam-matory properties of these polyphenols.The products of the HO-catalyzed reaction,particularly carbon mon-oxide (CO) and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli.In this context,it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to protec-tion against liver damage in various experimental mod-els.The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against various stressors in several pathological conditions. 关键词：红血素加氧酶肝胆功能一氧化碳氧化应激

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Natural heme oxygenase-1 inducers in hepatobiliary function

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