Isoflavone Regulates Lipid Metabolism via Expression of Related Genes in OVX Rats Fed on a High-fat Diet

查看全文 作　　者：XIAO-LIN [1]NA;JUNKO [2]EZAKI;FUMIE [2]SUGIYAMA;HONG-BIN [1]CUI;AND YOSHIKO [2]ISHIMI

机构地区：[1]Department of Food Nutrition and Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China;;[2]Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo 162-8636, Japan

出　　处：《Biomedical and Environmental Sciences》索引2008年第21卷第5期,共8页

基　　金：Special Coordination Funds for Promoting Science and Technology from Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government and Continuing Education Program of Talent Training Project with Japanese Loan. 摘　　要：Objective To investigate the effects of isoflavone on body weight,fat mass,and gene expression in relation to lipid metabolism.Methods Thirty-six female SD rats were ovariectomized or sham-operated and fed on a high-fat diet.Two months later,abdominal incision was made,blood was collected to separate serum,and the liver and adipose tissue were immediately collected and weighed.Some portions of these tissues were frozen in liquid nitrogen and stored at -80℃.Results Ovariectomy(OVX) with a high-fat diet could induce obesity in rats,while treatment with isoflavone significantly inhibited the increase in body weight and fat mass in abdomen.Serum total cholesterol and leptin were significantly decreased in isoflavone group,compared with the OVX group.The mRNA expression of liver fatty acid synthase(FAS) in the OVX group was significantly higher than that in sham-operated group,while this difference was not observed in the isoflavone group.The mRNA expression of liver hormone-sensitive lipase(HSL) in the OVX rats tended to be lower than that in the sham-operated rats.Furthermore,a large amount of isoflavone maintained the mRNA expression at a sham level.Conclusion Isoflavone may prevent obesity induced by ovariectomy with a high-fat diet,in part by modulating gene expression related to lipid metabolism. 关键词：异黄酮类脂物代谢作用卵巢切除术肥胖症基因表达

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Isoflavone Regulates Lipid Metabolism via Expression of Related Genes in OVX Rats Fed on a High-fat Diet

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