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Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy

查看全文 作　　者：Atsushi [1]Sofuni;Takao [1]Itoi;Fumihide [1]Itokawa;Takayoshi [1]Tsuchiya;Toshio [1]Kurihara;Kentaro [1]Ishii;Syujiro [1]Tsuji;Nobuhito [1]Ikeuchi;Fuminori [1]Moriyasu 高影响力作者 机构地区：[1]Department of Gastroenterology and Hepatology,Tokyo Medical University,Tokyo 160-0023,Japan高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第47期,共9页高影响力期刊 基　　金：Supported by (In part) UEGW 2004 (12th United European Gastroenterology Week),2004.9.25-30,Prague;awarded best abstract,DDW2005 (Digestive Disease Week),2005.5.14-19,Chicago;awarded Poster of Distinction,the World Congress of Gastroenterology 2005,2005.9.10-14,Montreal 摘　　要：AIM:To investigate if contrast-enhanced ultrasonography(CE-US) is useful for determining treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy by assessing changes in intratumor hemodynamics using CE-US with a contrast agent.METHODS:The subjects were 34 patients with unresectable advanced pancreatic cancer treated by chemotherapy.CE-US was assessed after every treatment(course) completion under the same conditions,and patients were divided into two groups according to the intratumor enhancement pattern:Vascular rich(R) group and vascular poor(P) group.RESULTS:After the second course of treatment,R group in intratumor hemodynamics had 18 patients,and P group had 16 patients.The reduction rates of serum CA19-9 level after chemotherapy which decreased to half or less of the baseline level were 2/15(0.1%) in P group,but 11/16(69%) in R group(P = 0.006).When the mean number of courses of chemotherapy and outcome were compared,P group had a mean number of courses of 4.9(R group,10.2) and mean survival time(MST) of 246 d(R group,402 d),showing that outcome was significantly better in R group(P=0.006).CONCLUSION:CE-US revealed that the change in intratumor blood flow correlated with both serum CA19-9 level and outcome.Patients with serum CA19-9 that decreased to less than half the baseline level,and patients with an abundant intratumor blood flow,had a significantly better outcome.Thus,CE-US is potentially useful for evaluating treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy. 关 键 词：胰腺癌 化学疗法 超声波扫描术 疗效
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