Vitamin E treatment for children with chronic hepatitis B:A randomized placebo controlled trial

查看全文 作　　者：Patrick [1,2]Gerner;Hans-Georg [3]Posselt;Andreas [4]Krahl;Antje [5]Ballauff;Albina [6]Innerhofer;Christa [6]Binder;Tobias G [7]Wenzl;Matthias [8]Zense;Ariadne [3]Hector;Gerhard [9]Dockter;Rüdiger [10]Adam;Jenny [11]Neubert;Martin [12]Claβen;Robert van [13]Gemmern;Stefan [14,15]Wirth

机构地区：[1]Children's Hospital Duisburg-Essen University,Klinik 2,Essen 45122,Germany;[2]Witten/Herdecke University,HELIOS Klinikum,Wuppertal,Germany;[3]Children's Hospital Frankfurt University,Frankfurt am Main 60590,Germany;[4]Children's Hospital,Darmstadt 64287,Germany;[5]Children's Hospital Essen University,Klinik 2,Essen 45122,Germany;[6]Children's Hospital St.Anna Wien,Austria 1090,Germany;[7]Children's Hospital Aachen University,Aachen 52074,Germany;[8]Children's Hospital St.Clemens,Münster 48153,Germany;[9]Children's Hospital Homburg University,Homburg/Saar 66421,Germany;[10]Children's Hospital Mannheim University,Mannheim 68167,Germany;[11]Children's Hospital Düsseldorf University,Düsseldorf 40225,Germany;[12]Children's Hospital Bremen University,Bremen 28195,Germany;[13]Pharmacy of HELIOS Klinikum,Wuppertal 42883,Germany;[14]Children's Hospital HELIOS Klinikum,Wuppertal,42283,Germany;[15]Witten/Herdecke University,Witten/Herdecke,Germany

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第47期,共6页

摘　　要：AIM:To evaluate the safety and efficacy of vitamin E in children with chronic hepatitis B.METHODS:We randomly assigned patients with chronic hepatitis B,positive for hepatitis B e antigen(HBeAg),to receive either vitamin E or placebo once daily for 6 mo in a 3:1 ratio and double-blind manner.The primary end point was HBeAg seroconversion,defined as the loss of HBeAg,undetectable levels of serum hepatitis B virus DNA,and the appearance of antibodies against HBeAg 12 mo after therapy.RESULTS:At baseline visit,49 patients had normal and 43 had increased serum aminotransferase levels.Twenty-nine patients did not respond to previous treatment with interferon-α or lamivudine.Seventy-six children completed the study;16 were non-compliant(n = 7),lost to follow-up(n = 7),or started another antiviral treatment(n = 3).Intention-to-treat analysis showed HBeAg seroconversion in 16 children(23.2%) treated with vitamin E and two(8.7%) in the placebo group(P = 0.13).Vitamin E was well tolerated.CONCLUSION:There is only a tendency that vitamin E may promote HBeAg seroconversion.Therefore larger studies are needed to clarify the role of antioxidants in the therapy of chronic hepatitis B. 关键词：垂直传播免疫力重复处理婴幼儿慢性乙肝

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Vitamin E treatment for children with chronic hepatitis B:A randomized placebo controlled trial

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