Hepcidin modulation in human diseases: From research to clinic

查看全文 作　　者：Alberto [1,2]Piperno;Raffaella [1]Mariani;Paola [2]Trombini;Domenico [3]Girelli

机构地区：[1]Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza, 20052, Italy;[2]Centre for Diagnosis and Treatment of Hemochromatosis and Iron Overload Diseases, San Gerardo Hospital, Monza, 20052, Italy;[3]Department of Clinical and Experimental Medicine, University of Verona, Verona, 37100, Italy

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第5期,共14页

基　　金：Supported by Ministry of University and Research, FIRB 2003 to AP;Association for the Study of Hemochromatosis and Iron Overload Diseases, Monza, to PT and RM;Telethon Italy (n° GGP06213);the Cariverona Foundation, Verona, Italy to DG 摘　　要：By modulating hepcidin production, an organism controls intestinal iron absorption, iron uptake and mobilization from stores to meet body iron need. In recent years there has been important advancement in our knowledge of hepcidin regulation that also has implications for understanding the physiopathology of some human disorders. Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a reliable assay of the hormone in biological fluids. Measurement of hepcidin in biological fuuids can improve our understanding of iron diseases and be a useful tool for diagnosis and clinical management of these disorders. We reviewed the literature and our own research on hepcidin to give an updated status of the situation in this rapidly evolving fi eld. 关键词：红血球生成血色沉着病贫血病缺铁临床

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Hepcidin modulation in human diseases: From research to clinic

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