Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats

查看全文 作　　者：MILENA [1]KATARANOVSKI;SRDJA [1]JANKOVIC;DRAGAN [1]KATARANOVSKI;JELENA STO[1]IC;DESA [2]BOGOJEVIC

机构地区：[1]Department of Ecology,Institute for Biological Research'Sinia Stankovi',Bulevar Despota Stefana 142,11060 Belgrade,Serbia;[2]Department of Molecular Biology,Institutefor Biological Research'Sinia Stankovi',Bulevar Despota Stefana 142,11060 Belgrade,Serbia

出　　处：《Biomedical and Environmental Sciences》索引2009年第22卷第1期,共7页

基　　金：supported by the Ministry of Science and Environmental Protection of the Republic of Serbia(No.143038). 摘　　要：Objective To examine the presence of gender difierences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes.Methods Basic aspects of this response were evaluated,including plasma levels of inflammatory cytokines tumor necrosis factor(TNF)and interleukin-6(IL-6)and of major rat acute phase protein alpha 2-macroglobulin(alpha2-M),as soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes.as cellular indicators of inflammation.Results Differential increases of IL-6 and alpha 2-M(higher in males than in females)in peripheral blood cell counts and types(leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females) and in levels of neutrophil priming (higher in males vs females)were noted.Conclusion The data document a more intense inflammatory response to cadmium administration in males The sex difierences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal. 关键词：性差别男人女人镉中毒

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Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats

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