Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2

查看全文 作　　者：GUO HongXiong, CUN Wei, LIU LongDing, WANG LiChun, ZHAO HongLing, DONG ChengHong & LI QiHan Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China These authors contributed equally to this work

出　　处：《Science China(Life Sciences)》索引2007年第50卷第4期,共6页

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 30570081) 摘　　要：As a product of HSVI immediate-early gene, ICP22 is capable of interacting with various cellular tran-scriptive and regulatory molecules during viral infection so as to impact the normal cellular molecular mechanism. ICP22 expressed in transfected cells can push the cells’ entering into S phase with binding to mdm-1 promoter region and impact its trans-transcription activating effect by P53. Consequently, the MDM-2 binds to P53, and the degradation effects by the ubiquitous pathway are decreased, improving indirectly the P53 levels in cells and making the cells progress into the S phase. 关键词：HSV ICP22 P53 MDM-2

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Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2

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