Expression of Bcl-2 in cells with different telomerase activities

查看全文 作　　者：CHEN [1,2]Jing;REN [1]Jianguo;ZHENG [2]Jianyu;CAI [1]Guoping;DAI [1]Yaoren 机构地区：[1]Department of Biological Sciences and Biotechnology,Tsinghua University,National Key Laboratory of Biomembrance and Membrance Biotechnology,Beijing 100084,China;[2]Institute for Molecular Biology,Nankai University,Tianjin 300071,China 出　　处：《Chinese Science Bulletin》索引2001年第46卷第23期,共5页 基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39670363). 摘　　要：Both tclomerase and Bcl-2 are important genes in controlling apoptosis. The activation of telomerase and the abnormal regulation of Bcl-2 are also closely related to carcinogenesis. However, little is known about the linkage between telomerase and Bcl-2. The effect of activated telomerase on the expression of Bcl-2 has been investigated. It is demonstrated that in tumor and transformed cells with higher telomerase activity, Bcl-2 expression is significantly lower than that in telomerase negative or less telomerose activity cells. Further study showed that in the telomerase gene-transformed 2BS-fibroblasts, Bcl-2 expression is inhibited significantly while the exogenous telomerase catalyticsubunit gene is re-expressed in flbroblasts. Results indicated that there might be a certain linkage between the expression of telomerase and Bcl-2, and overexpression of exogenous telomerase gene might down regulate the expression of Bcl-2. 关 键 词：TELOMERE TELOMERASE Bcl-2.