Acute pancreatitis:Etiology and common pathogenesis

查看全文 作　　者：Guo-Jun Wang Chun-Fang Gao Dong Wei Cun Wang Si-Qin [1]Ding

机构地区：[1]Institute of Digestive Surgery and Department of General Surgery, 150 Hospital of Chinese PLA, Gaoxin District, Luoyang 471031, Henan Province, China

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第12期,共4页

摘　　要：Acute pancreatitis is an inflammatory disease of the pancreas.The etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries worldwide.Many causes of acute pancreatitis have been discovered,but the pathogenetic theories are controversial.The most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic duct.The majority ofinvestigators accept that the main factors for acute billiary pancreatitis are pancreatic hyperstimulation and bile-pancreatic duct obstruction which increase pancreatic duct pressure and active trypsin reflux.Acute pancreatitis occurs when intracellular protective mechanisms to prevent trypsinogen activation or reduce trypsin activity are overwhelmed.However,little is known about the other acute pancreatitis.We hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common pathogenesis.Pancreatic hyperstimulation and pancreatic duct obstruction increase pancreatic duct pressure,active trypsin reflux,and subsequent unregulated activation of trypsin within pancreatic acinar cells.Enzyme activation within the pancreas leads to auto-digestion of the gland and local inflammation.Once the hypothesis is confirmed,traditional therapeutic strategies against acute pancreatitis may be improved.Decompression of pancreatic duct pressure should be advocated in the treatment of acute pancreatitits which may greatly improve its outcome. 关键词：急性胰腺炎发病机制病因急性胆源性胰腺炎胰管阻塞胰蛋白酶炎症性疾病胰胆管梗阻

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Acute pancreatitis:Etiology and common pathogenesis

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