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Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

查看全文 作　　者：Jun Seok [1]Lee;Sang Heum [2]Kim;Dae Won [1]Jun;Jee Hye [3]Han;Eun Chul [4]Jang;Ji Young [1]Park;Byung Kwan [1]Son;Seong Hwan [1]Kim;Yoon Ju [1]Jo;Young Sook [1]Park;Yong Soo [5]Kim 高影响力作者 机构地区：[1]Department of Internal Medicine,Eulji University School of Medicine;[2]Department of Radiology,Eulji University School of Medicine;[3]Department of Family Medicine,Eulji University School of Medicine;[4]Department of Occupational and Environmental Medicine,College of Medicine,Soonchunhyang University;[5]Department of Radiology,Hanyang University School of Medicine高影响力机构 出　　处：《World Journal of Gastroenterology》索引2009年第15卷第15期,共7页高影响力期刊 摘　　要：AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. 关 键 词：代谢综合征 内脏脂肪 正常胰腺 临床意义 胰岛素抵抗 ALT水平 logistic 谷草转氨酶
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