Prognostic Factors of Ampulla of Vater Carcinoma after Radical Surgery

查看全文 作　　者：Dongbing Zhao Yongkai Wu Yi Shan Chengfeng Wang Ping [1]Zhao

机构地区：[1]Department of Abdomen Surgery, CancerHospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China

出　　处：《Chinese Journal of Clinical Oncology》索引2009年第6卷第2期,共5页

摘　　要：OBJECTIVE Ampullary carcinoma is a rare disease with betterprognosis than other periampullary neoplasms. This studyinvestigated the association between clinicopathologic factors andprognosis after radical resection of ampulla of Vater carcinoma.METHODS Clinical data from 105 patients who underwentradical pancreaticoduodenectomy from January 1990 to December2005 were retrospectively analyzed by the Kaplan-Meier method,log-rank test, and the Cox proportional hazard model.RESULTS The in-hospital mortality rate was 8.6%, the lymphnode metastasis rate was 37.1%, and the five-year survival ratewas 42.8%. Pancreatic involvement (P = 0.027), tumor diameter (P= 0.008), T stage (P = 0.003), TNM stage (P < 0.001), and number ofmetastatic lymph nodes (P < 0.001) were associated with prognosiswhen the univariate analysis was used. Multivariate analysisshowed that the number of lymph node metastases (P < 0.001;OR: 1.923; CI: 1.367-2.705) and tumor diameter (P = 0.03; OR: 1.432;CI: 1.035-1.981) were the independent prognostic factors.CONCLUSION The number of metastatic lymph nodes andtumor diameter are important pathologic factors predictingprognosis of ampulla of Vater carcinoma after radical resection,and lymph node dissection during the radical surgery effectivelyimproves the survival rate. 关键词：乏特氏壶腹癌预后因素根治术后淋巴结转移率 COX比例风险模型胰十二指肠切除术 VATER壶腹癌临床病理因素

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Prognostic Factors of Ampulla of Vater Carcinoma after Radical Surgery

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