Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans

查看全文 作　　者：XIAO [1,2,3]Jing RUI [2,3]Qi GUO [1,2,3]Yuling CHANG [1,2,3]Xingya WANG [2,3]Dayong

机构地区：[1]College of Life Sciences, Nanjing Normal University, Nanjing 210046, China;[2]Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009, China;[3]Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Nanjing 210009, China

出　　处：《Journal of Environmental Sciences》索引2009年第21卷第6期,共7页

基　　金：supported by the National Natural Science Foundation of China (No. 30771113, 30870810);the Program for New Century Excellent Talents in University 摘　　要：We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese(Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure(6 h) to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn(2.5 μmol/L) for 48 h.In contrast,prolonged exposure(48 h) to high Mn concentrations(75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure(48 h) to high concentrations(75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. 关键词：秀丽隐杆线虫氧化应激反应高锰寿命繁殖超氧化物歧化酶诱导发育

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Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans

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