Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

查看全文 作　　者：Walkíria Wingester Vilas-[1]Boas;Antnio Ribeiro-Oliveira [2]Jr;Regina Maria [3]Pereira;Renata da Cunha [2]Ribeiro;Jerusa [1]Almeida;Ana Paula [1]Nadu;Ana Cristina Simoes e [4]Silva;Robson Augusto Souza dos [1]Santos

机构地区：[1]Laboratory of Hypertension, Department of Physiology, Biological Sciences institute, Federal University of Minas Gerais, Av. Antonio Carlos, 6627, Belo Horizonte, MG, 31270-901, Brazil;[2]Laboratory of Endocrinology, Department of Medicine, Faculty of Medicine, Federal University of Minas Gerais, Av. Alfredo Balena, 190, Belo Horizonte, MG, 30130-100, Brazil;[3]Hospitalar Foundation of the State of Minas Gerais, FHEMIG, Belo Horizonte, MG, Brazil;[4]Department of Pediatrics,Faculty of Medicine, Federal University of Minas Gerais, Av.Alfredo Balena, 190, Belo Horizonte, MG, 30130-100, Brazil

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第20期,共8页

基　　金：Supported by Fundacode Amparo à Pesquisa do Estado de Minas Gerais, Conselho Nacional de Desenvolvimento Científico e Tecnológico, FAPEMIG/CNPQ-PRONEX (Grupos de Excelência),Ministério de Ciência e Tecnologia/CNPq/ FAPEMIG-INCT-Nano-Biofar 摘　　要：AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. 关键词：血管紧张素血流动力学肝硬化人类

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Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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