The molecular mechanism of photodynamic therapy to fibrosis:Regulation on the pyridinoline cross-link formation in collagen

查看全文 作　　者：ZHANG JuCheng1,2,LIU Wei1,2,YI ZhongZhou1,2,CHEN Rui1,2,LI Ying1,2 & MIN Yong1,2 1 Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province,Honghe University,Mengzi 661100,China;2 School of Science,Honghe University,Mengzi 661100,China

出　　处：《Chinese Science Bulletin》索引2009年第54卷第13期,共5页

基　　金：Supported by the Natural Science Foundation of Yunnan Province (Grant No.2005C0078M);Scientific Research Startup Project Foundation of Honghe University (Grant No.XSS07012) 摘　　要：Fibrotic processes in tissues are characterised by an excessive accumulation of collagen containing increased levels of pyridinoline cross-links,which has been taken as an important criterion to diagnose the fibrosis.Hypocrellin B(HB) is a natural photosensitizer with excellent photodynamic activity but very low dark-toxicity.In the current work,main purpose was to clarify if photodynamic action of HB could be applied to regulating the level of pyridinoline cross-link in collagen.To use gelatin as a model collagen,it was observed that the pyridinoline cross-link formation was effectively degraded by HB photodynamic action in the gelatin,suggesting the level of pyridinoline cross-link formation in collagen may be photodynamically regulated to a normal level.Furthermore,mechanism of the photodynamic action of HB was studied. 关键词：胶原蛋白肝纤维化分子机制光动力疗法交联吡啶治疗原水

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The molecular mechanism of photodynamic therapy to fibrosis:Regulation on the pyridinoline cross-link formation in collagen

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