Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD

查看全文 作　　者：Walid Ben [1]Aleya;Imen [1]Sfar;Leila [2]Mouelhi;Houda [1]Aouadi;Mouna [1]Makhlouf;Salwa Ayed-[1]Jendoubi;Samira [3]Matri;Azza [3]Filali;Taoufik [2]Najjar;Taeib Ben [1]Abdallah;Khaled [1]Ayed;Yousr [1]Gorgi

机构地区：[1]Laboratory of Immunology, EPS Charles Nicolle, 1006 Bab Saadoun, Tunis 1006, Tunisia;[2]Department of Gastroenterology, EPS Charles Nicolle, Tunis 1006, Tunisia;[3]Department of Gastroenterology, La Rabta, Tunis 1006, Tunisia

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第29期,共6页

基　　金：Supported by Laboratory of Immunology, EPS Charles Nicolle,Tunis, Tunisia 摘　　要：AIM: To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population. METHODS: The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (Pcorrected = 0.009). The analysis ofinflammatory bowel disease patients according to clinical behavior revealed no difference. CONCLUSION: Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population. 关键词：溃疡性结肠炎多态性分析基因启动子突尼斯患者限制性片段长度多态性 FAS 协会

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Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD

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