Applicability and variability of liver stiffness measurements according to probe position

查看全文 作　　者：Patrick [1]Ingiliz;Kim Pav [1]Chhay;Mona [2]Munteanu;Pascal [1]Lebray;Yen [1]Ngo;Dominique [3]Roulot;Yves [4]Benhamou;Dominique [4]Thabut;Vlad [4]Ratziu;Thierry [4]Poynard

机构地区：[1]Dominique Thabut, Vlad Ratziu, Thierry Poynard, AP-HP Hospital Group Pitié-Salpêtrière, Hepatology Department,47-83 Hospital Boulevard, Paris 75651, France;[2]BioPredictive,40 Bac street, Paris 75007, France;[3]AP-HP, Hepatology Department, Avicenne hospital,Bobigny 93000,France;[4]AP-HP Hospital Group Pitié-Salpêtrière, Hepatology Department,47-83 Hospital Boulevard, Paris 75651, France

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第27期,共7页

摘　　要：AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a signif icant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03).CONCLUSION: The anterior position of the probe should be the fi rst choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position. 关键词：硬度测量适用性肝脏可变性探头位置测量范围一致性肌病

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Applicability and variability of liver stiffness measurements according to probe position

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