Overview of immunosuppression in liver transplantation

查看全文 作　　者：Anjana A [1]Pillai;Josh [2]Levitsky

机构地区：[1]Department of Transplant Surgery,Northwestern Memorial Hospital;[2]Department of Hepatology,Northwestern Memorial Hospital

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第34期,共9页

摘　　要：Continued advances in surgical techniques and immunosuppressive therapy have allowed liver transplantation to become an extremely successful treatment option for patients with end-stage liver disease.Beginning with the revolutionary discovery of cyclosporine in the 1970s,immunosuppressive regimens have evolved greatly and current statistics confirm one-year graft survival rates in excess of 80%. Immunosuppressive regimens include calcineurin inhibitors,anti-metabolites,mTOR inhibitors,steroids and antibody-based therapies.These agents target different sites in the T cell activation cascade,usually by inhibiting T cell activation or via T cell depletion.They are used as induction therapy in the immediate periand post-operative period,as long-term maintenance medications to preserve graft function and as salvage therapy for acute rejection in liver transplant recipients. This review will focus on existing immunosuppressive agents for liver transplantation and consider newer medications on the horizon. 关键词：免疫抑制剂肝移植 T细胞活化治疗方案免疫疗法数据证实排斥反应肾功能

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Overview of immunosuppression in liver transplantation

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