Advances in diagnosis,treatment and palliation of cholangiocarcinoma:1990-2009

查看全文 作　　者：Murad [1]Aljiffry;Mark J [1]Walsh;Michele [1]Molinari

机构地区：[1]Department of Surgery,Queen Elizabeth II Health Science Centre,Dalhousie University

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第34期,共23页

摘　　要：Several advances in diagnosis,treatment and palliation of cholangiocarcinoma(CC)have occurred in the last decades.A multidisciplinary approach to this disease is therefore recommended.CC is a relatively rare tumor and the main risk factors are:chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree.While the incidence of intra-hepatic CC is increasing,the incidence of extra-hepatic CC is trending down.The only curative treatment for CC is surgical resection with negative margins.Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo-radiation therapy.Magnetic resonance imaging/magnetic resonance cholangiopancreatography,positron emission tomography scan,endoscopic ultrasound and computed tomography scans are the most frequently used modalities for diagnosis and tumor staging.Adjuvant therapy,palliative chemotherapy and radiotherapy have been relatively ineffective for inoperable CC.For most of these patients biliary stenting provides effective palliation.Photodynamic therapy is an emerging palliative treatment that seems to provide pain relief,improve biliary patency and increase survival. The clinical utility of other emerging therapies such as transarterial chemoembolization,hepatic arterial chemoinfusion and high intensity intraductal ultrasound needs further study. 关键词：放射治疗诊断胆管磁共振成像癌手术切除先天性畸形正电子发射

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Advances in diagnosis,treatment and palliation of cholangiocarcinoma:1990-2009

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