Modifi cation of sleep architecture in an animal model of experimental cirrhosis

查看全文 作　　者：Anabel Jiménez-[1]Anguiano;Vanessa Díaz-[1]Medina;Blanca Eugenia Farfán-[2]Labonne;Gloria Giono-[2]Chiang;David [3]Kersenobich;Mario García-[1]Lorenzana;Maria Concepción Gutiérrez-[2]Ruiz;Javier Velázquez-[1]Moctezuma

机构地区：[1]Area of Neuroscience Department of Biology of Reproduction, Universidad Autónoma Metropolitana-Iztapalapa, CP 09340, Mexico City, Mexico;[2]Cell Physiology Laboratory, Department of Health Sciences, Universidad Autónoma Metro-politana-Iztapalapa, CP 09340, Mexico City, Mexico;[3]Unit of Liver, Pancreas and Motility, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, D.F CP 09340, Mexico

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第41期,共5页

基　　金：Supported by Grant 50633 from CONACyT to Jiménez-Anguiano A 摘　　要：AIM: To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCl4 administration. METHODS: Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were implanted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological conf irmation of cirrhosis was performed after 11 wk.RESULTS: The results showed a progressive decrease in total wake time that reached statistical signif icance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep (SWS) and rapid eye movement sleep (REM sleep) in most of the 11 wk. SWS showed no signif icant variations.During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION: These data suggest that hepatic failure produced by CCl4 administration is capable of modifying the sleep pattern even after only a few doses. 关键词：睡眠模式肝硬化动物模型结构改造实验性 WISTAR大鼠慢波睡眠大鼠模型

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Modifi cation of sleep architecture in an animal model of experimental cirrhosis

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