Rapid determination of pharmaceuticals from multiple therapeutic classes in wastewater by solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry

查看全文 作　　者：SUI Qian HUANG Jun DENG ShuBo YU [1]Gang

机构地区：[1]POPs Research Centre, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Science Bulletin》索引2009年第54卷第24期,共11页

基　　金：Supported by by the National Science Fund for Distinguished Young Scholars (Grant No. 50625823) ;National Natural Science Foundation of China (Grant No. 50538090) 摘　　要：A new analytical method utilizing ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS) has been developed to determine 16 pharmaceuticals from 8 therapeutic classes in wastewater: bezafibrate, clofibric acid, carbamazepine, caffeine, chloramphenicol, diclofenac, gemfibrozil, indomethacin, ketoprofen, mefenamic acid, metoprolol, nalidixic acid, N,N-diethyl-metatoluamide, propranolol, sulpiride and trimethoprim. Key parameters of MS/MS, UPLC and solid phase extraction (SPE) were optimized. In general, recovery of target pharmaceuticals was over 70% for the wastewater effluent samples and 50% for the influent samples. The effects of matrix suppression, loss during the pretreatment as well as instrument variability were successfully corrected by two internal standards, and acceptable relative recovery was obtained. Target compounds were quantitatively analyzed using multiple reaction monitoring (MRM) mode, and the detection limits ranged from 0.3 to 20 ng/L. A detailed study, matrix effect in effluent wastewater was also present. The method was applied to detecting pharmaceuticals in the wastewater from three wastewater treatment plants (WWTPs) in Beijing, China and the results demonstrated that most target compounds were detectable in both the influent and effluent, with the mean concentrations ranging from 20.5 to 5775.6 ng/L and 4.6 to 418.6 ng/L, respectively. 关键词：高效液相色谱串联质谱法固相萃取废水药品快速测定治疗污水处理厂

相关文献

参考文献（12）
引证文献（18）
耦合文献（15）

参考文献(12)

引证文献(18)

耦合文献(15)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Rapid determination of pharmaceuticals from multiple therapeutic classes in wastewater by solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry

参考文献(12)

引证文献(18)

耦合文献(15)

用户提示