Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease

查看全文 作　　者：Krzysztof [1]Fyderek;Magdalena [2]Strus;Kinga Kowalska-[1]Duplaga;Tomasz [2]Gosiewski;Andrzej [1]Wedrychowicz;Urszula Jedynak-[1]Wasowicz;Malgorzata [1]Sladek;Stanislaw [1]Pieczarkowski;Pawel [3]Adamski;Piotr [2]Kochan;Piotr B [2]Heczko

机构地区：[1]Department of Pediatrics,Gastroenterology and Nutrition,Polish-American Children's Hospital,Jagiellonian University Medical College,265 Wielicka Str.,30-663 Cracow,Poland;[2]Chair of Microbiology,Jagiellonian University Medical College,18 Czysta Str.,31-121 Cracow,Poland;[3]Institute of Nature Conservation,Polish Academy of Sciences,33 Mickiewicza Ave.,31-120 Cracow,Poland

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第42期,共8页

基　　金：Supported by Polish Ministry of Science and Higher Education,Grant No.3PO5E09125 摘　　要：AIM:To assess the mucosa-associated bacterial microflora and mucus layer in adolescents with inflammatory bowel disease(IBD) .METHODS:Sixty-one adolescents(mean age 15 years,SD ± 4.13) were included in the study.Intestinal biopsies from inflamed and non-inflamed mucosa of IBD patients and from controls with functional abdominal pain were cultured under aerobic and anaerobic conditions.The number of microbes belonging to the same group was calculated per weight of collected tissue.The mucus thickness in frozen samples was measured under a fluorescent microscope.RESULTS:The ratios of different bacterial groups in inflamed and non-inflamed mucosa of IBD patients and controls were specific for particular diseases.Streptococcus spp.were predominant in the inflamed mucosa of Crohn's disease(CD) patients(80% of all bacteria) ,and Lactobacillus spp.were predominant in ulcerative colitis patients(90%) .The differences were statistically significant(P = 0.01-0.001) .Lower number of bifidobacteria was observed in the whole IBD group.A relation was also found between clinical and endoscopic severity and decreased numbers of Lactobacillus and,to a lesser extent,of Streptococcus in biopsies from CD patients.The mucus layer in the inflamed sites was significantly thinner as compared to controls(P = 0.0033) and to non-inflamed areas in IBD patients(P = 0.031) .CONCLUSION:The significantly thinner mucosa of IBD patients showed a predominance of some aerobes specific for particular diseases,their numbers decreased in relation to higher clinical and endoscopic activity of the disease. 关键词：细菌菌群青少年粘膜厚度粘液炎症肠

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Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease

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